Clinical Observation of Huaihua Powder Retention Enema Eombined with Mesalazine in the Treatment of Patients with Damp-heat Ulcerative Colitis
槐花散保留灌肠联合美沙拉嗪对湿热型溃疡性结肠炎的临床疗效观察

摘要

目的 观察槐花散药液保留灌肠联合美沙拉嗪治疗湿热型溃疡性结肠炎的临床疗效。方法 选取2021年10月至2022年10月湖北省中医院肛肠科收治的56名湿热型溃疡性结肠炎患者作为研究对象，并按随机数字表法随机分为试验组（28例）和对照组（28例），对照组采用用美沙拉嗪肠溶片（每日4次，每次1g）口服，和美沙拉嗪灌肠液（每日1次，每次4g）灌肠联合用药，试验组在此基础上加用槐花散煎汤保留灌肠，对比两组患者溃疡性结肠炎活动性的改良Mayo评分系统、Mayo内镜评分系统中二者评分变化情况、临床疗效及症状缓解所需天数。结果 治疗结束后，试验组患者的改良Mayo评分及Mayo内镜评分略低于对照组，另试验组症状缓解天数明显低于对照组（t=2.54，P=0.003）；试验组中总有效率92.9%，对照组中总有效率89.3%，二者采用秩和检验进行比较（P=0.679，P>0.05），差异不具有统计学意义。结论 槐花散药液保留灌肠联合美沙拉嗪能够显著改善湿热型溃疡性结肠炎患者的临床症状，且能在更短的时间内改善患者的临床症状，提高患者的生活质量。

Abstract

Objetive To observe the clinical efficacy of Huaihua powder retention enema combined with mesalazine in the treatment of damp-heat ulcerative colitis.
Methods From October 2021 to October 2022, 56 patients with damp-heat ulcerative colitis admitted to the Department of Anorectal Diseases of Hubei Provincial Hospital of Traditional Chinese Medicine were selected as the study subjects, and randomly divided into an experimental group (28 cases) and a control group (28 cases) according to a random number table method. The control group was administered orally with mesalazine enteric coated tablets (4 times a day, 1 g each time), and combined with mesalazine enema liquid (1 time a day, 4 g each time), On this basis, the experimental group was added with Huaihua Sanjian Decoction for retention enema, and the score changes, clinical efficacy, and days required for symptom relief in the modified Mayo scoring system and Mayo endoscopic scoring system for ulcerative colitis activity in the two groups were compared.
Results After treatment, the modified Mayo score and Mayo endoscopy score of patients in the experimental group were slightly lower than those in the control group, and the days of symptom relief in the experimental group were significantly lower than those in the control group (t=2.54, P=0.003); The total effective rate in the test group was 92.9%, and the total effective rate in the control group was 89.3%. The two groups were compared using rank sum test (P=0.679, P>0.05), and the difference was not statistically significant.
Conclusion   Huaihua powder liquid retention enema combined with mesalazine can significantly improve the clinical symptoms of patients with damp-heat ulcerative colitis, and can improve their clinical symptoms in a shorter time, improving their quality of life.