Clinical efficacy of aripiprazole combined with paroxetine in the treatment of schizophrenia and its effect on glycolipid metabolism
阿立哌唑联合帕罗西汀治疗精神分裂症的临床疗效及对糖脂代谢的影响探讨

摘要

目的 对阿立哌唑联合帕罗西汀在精神分裂症临床治疗中的效果以及治疗过程中患者糖代谢状况进行分析。方法 选择2019年1月至2022年3月间来我院进行治疗的100例精神分裂症患者作为研究对象，利用数字法均分为对照组（n=50）及观察组（n=50），对照组患者入院后治疗过程中主要采用的是盐酸帕罗西汀片，而观察组患者除服用盐酸帕罗西汀后，采取了阿立哌唑片进行联合治疗。经过四周临床治疗后，对两组患者临床治疗效果进行对比，同时对两组患者治疗前后阴性与阳性症状量表（PANSS）评分、认知功能是查量表（CASI）、及各项实验室指标和不良反应率进行对比。结果 经四周治疗后对照组患者的整体治疗有效率为74%，观察组患者整体治疗有效率为94%。经治疗后两组患者的阴性症状、阳性症状PANSS总分均出现明显下降，且与对照组相比较，观察组患者下降幅度明显更大，差异显著，P＜0.05。经四周服药治疗后两组患者各项实验室指标均明显升高，与对照组相比较，观察组患者的各项指标明显更低，差异显著，P＜0.05。结论 在临床治疗精神分裂症的过程中阿立哌唑与帕罗西汀联合治疗具有更加明显疗效，可使患者认知功能、临床症状表现得到积极改善，对于患者糖代谢影响相对较小，具有较高安全性。

Abstract

Objective To analyze the effect of aripiprazole combined with paroxetine in the clinical treatment of schizophrenia and the status of glucose metabolism during the treatment.
Methods A total of 100 patients with schizophrenia who came to our hospital for treatment from January 2019 to March 2022 were selected as research objects, and were divided into control group (n=50) and observation group (n=50) by digital method. Patients in the control group were mainly treated with paroxetine hydrochloride tablets after admission, while patients in the observation group were treated with paroxetine hydrochloride. Aripiprazole tablets were used in combination therapy. After four weeks of clinical treatment, the clinical effects of the two groups of patients were compared, and the Negative and positive Symptom Scale (PANSS) score, cognitive Function Scale (CASI), various laboratory indicators and adverse reaction rate of the two groups of patients before and after treatment were compared.
Results After four weeks of treatment, the overall effective rate was 74% in the control group and 94% in the observation group. After treatment, the total score of PANSS with negative symptoms and positive symptoms in both groups decreased significantly, and compared with the control group, the decrease range of patients in the observation group was significantly greater, the difference was significant (P < 0.05). After four weeks of drug treatment, the laboratory indexes of Zhang Zu patients were significantly increased, and compared with the control group, the indexes of patients in the observation group were significantly lower, the difference was significant (P < 0.05).
Conclusion   In the clinical treatment of schizophrenia, the combined treatment of aripiprazole and Paxil has more obvious efficacy, which can improve the cognitive function and clinical symptoms of patients, and has relatively little effect on the glucose metabolism of patients, with high safety.