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国际临床研究杂志

International Journal of Clinical Research

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International Journal of Clinical Research. 2023; 7: (4) ; 10.12208/j.ijcr.20230155 .

Effect of simplified autologous platelet-rich Gel on diabetic wounds
简化自体富血小板凝胶在糖尿病性创面的疗效观察

作者： 蔡斌, 杨力 *, 庞远翔, 郭贤钊, 熊丽婵

广西玉林市第一人医院烧伤整形外科 广西玉林

*通讯作者： 杨力,单位：广西玉林市第一人医院烧伤整形外科 广西玉林；

引用本文: 蔡斌, 杨力, 庞远翔, 郭贤钊, 熊丽婵 简化自体富血小板凝胶在糖尿病性创面的疗效观察[J]. 国际临床研究杂志, 2023; 7: (4) : 6-10.
Published: 2023/4/13 2:01:28

摘要

目的 探讨简化自体富血小板凝胶（APG）治疗糖尿病性创面的临床疗效。方法 笔者单位2017年5月-2021年5月收治糖尿病性创面患者108例，采用随机化法分APG观察组与标准组，各54例，均予基础治疗和创面常规治疗。记录基准创面开始4周内创面变化，观察至创面愈合或8周比较两组创面愈合时间、疗效、住院时间、住院费用等。结果 观察组与对照组创面住院时间差异无统计学意义（P＞0.05）；疗效、愈合时间、住院费用低于对照组（P＜0.05）；1周内，两组创面变化无统计学差异（P＞0.05），但治疗1周后，观察组创面面积均显著小于对照组同时间水平（P<0.05）；两组治疗期间均未发生相关不良事件。结论 简化版APG治疗早期糖尿病创面的临床疗效确切，可缩短创面愈合进程，治疗费用优于传统常规换药。

关键词： 自体富血小板凝胶；糖尿病性创面；疗效

Abstract

Objetive To investigate the clinical effect of simplified autologous platelet-rich Gel (APG) in the treatment of diabetic wounds.
Methods A total of 108 patients with diabetic wounds were recruited, from May, 2017 to May, 2021.All patients were randomly assigned into the conventional group(n=54) and PRG group(n=54) by the method of random number generator. Both groups were treated with general support and wound managed as usual. The Wound Healing Time, curative effect, hospitalization time and hospitalization expenses were observed and compared between the two groups within 4 weeks after the baseline wound.
Results There was no significant difference in the wound length of hospitalization between the two groups (P＜0.05), the curative effect, Healing Time and hospitalization expenses were better than those of the Control Group (P＜0.05), and there was no significant difference in wound length between the two groups within 1 week (P > 0.05) , the wound area in the observation group was significantly smaller than that in the control group at the same time (P＜0.05).
Conclusion   The simplified version of APG is more effective than the conventional dressing change in the treatment of early diabetic wounds.

Key words： Autologous platelet-rich; diabetic wounds; curative effect

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