International Journal of Clinical Research
International Journal of Clinical Research. 2023; 7: (1) ; 10.12208/j.ijcr.20230004 .
总浏览量: 526
暨南大学附属珠海医院（珠海市人民医院） 广东珠海
*通讯作者： 冯颖青,单位：暨南大学附属珠海医院（珠海市人民医院） 广东珠海；
勃起功能障碍（ED）作为当今社会一大棘手的常见疾病，不仅在中老年男性中有较高的发病率，其在年轻男性中的患病率也呈上升趋势。目前的研究广泛认为，ED是一种血管性疾病，与高血压的发生密切相关，本综述总结了目前高血压与ED的相关发病机制，为未来高血压合并ED患者的临床诊治及预防有一定的指导意义。
Erectile dysfunction (ED), as a common and intractable disease in today's society, has a high incidence rate not only in middle-aged and elderly men, but also in young men. The current research widely believes that ED is a vascular disease, which is closely related to the occurrence of hypertension. This review summarizes the current pathogenesis of hypertension and ED, which has certain guiding significance for the clinical diagnosis, treatment and prevention of hypertension patients with ED in the future.
[1] Unger, T., et al., 2020 International Society of Hyper- tension global hypertension practice guidelines. J Hyper- tens, 2020. 38(6): p. 982-1004.
[2] Ma, W., et al., iTRAQ-based identification of differe- ntially expressed proteins in ED rat model induced by cold stress combined with environmental oestrogen. Andrologia, 2022: p. e14382.
[3] 刘绍明等, 基于系统生物学理论对高血压ED发病机制的探讨. 现代诊断与治疗, 2020. 31(22): 第3560-3564页.
[4] Wu, F., Y. Lin and Q. Liu, The emerging role of aldo- sterone/mineralocorticoid receptors in the pathogenesis of erectile dysfunction. Endocrine, 2018. 61(3): p. 372-382.
[5] Mitidieri, E., et al., Pharmacology and perspectives in erectile dysfunction in man. Pharmacol Ther, 2020. 208: p. 107493.
[6] Kenia, P.N., et al., Blockade of Toll-Like Receptor 4 Attenuates Erectile Dysfunction in Diabetic Rats. The Journal of Sexual Medicine, 2018. 15(9).
[7] Zhang, H., et al., MyD88 overexpression deteriorates Ang-II-induced ED via upregulating MPO and COX2 and downregulating eNOS in the corpus cavernosum of rats. Journal of cellular biochemistry, 2018. 120(5).
[8] Caillon, A., P. Paradis and E.L. Schiffrin, Role of immune cells in hypertension. British journal of pharmacology, 2019. 176(12).
[9] Zhang, Y., et al., Angiotensin II Silencing Alleviates Erectile Dysfunction Through Down-Regulating the Rhoa/Rho Kinase Signaling Pathway in Rats with Diabetes Mellitus. Cell Physiol Biochem, 2018. 45(1): p. 419-427.
[10] Karakurt, D., et al., [Evaluation of the relationship between erectile dysfunction and epicardial fat tissue thickness and carotid intima-media thickness in patients with newly diagnosed hypertension]. Turk Kardiyol Dern Ars, 2020. 48(8): p. 746-753.