International Journal of Clinical Research

您当前位置:首页 > 精选文章

International Journal of Clinical Research. 2023; 7: (1) ; 10.12208/j.ijcr.20230004 .

Research progress on the correlation between hypertension and erectile dysfunction

作者: 徐思颖, 冯颖青*,

暨南大学附属珠海医院(珠海市人民医院) 广东珠海

*通讯作者: 冯颖青,单位:暨南大学附属珠海医院(珠海市人民医院) 广东珠海;

引用本文: 徐思颖, 冯颖青, 高血压与勃起功能障碍的相关性研究进展[J]. 国际临床研究杂志, 2023; 7: (1) : 10-12.
Published: 2023/1/13 16:12:43



关键词: 高血压;勃起功能障碍;机制预测


Erectile dysfunction (ED), as a common and intractable disease in today's society, has a high incidence rate not only in middle-aged and elderly men, but also in young men. The current research widely believes that ED is a vascular disease, which is closely related to the occurrence of hypertension. This review summarizes the current pathogenesis of hypertension and ED, which has certain guiding significance for the clinical diagnosis, treatment and prevention of hypertension patients with ED in the future.

Key words: Hypertension; Erectile dysfunction; Mechanism prediction

参考文献 References

[1] Unger, T., et al., 2020 International Society of Hyper- tension global hypertension practice guidelines. J Hyper- tens, 2020. 38(6): p. 982-1004.

[2] Ma, W., et al., iTRAQ-based identification of differe- ntially expressed proteins in ED rat model induced by cold stress combined with environmental oestrogen. Andrologia, 2022: p. e14382.

[3] 刘绍明等, 基于系统生物学理论对高血压ED发病机制的探讨. 现代诊断与治疗, 2020. 31(22): 第3560-3564页.

[4] Wu, F., Y. Lin and Q. Liu, The emerging role of aldo- sterone/mineralocorticoid receptors in the pathogenesis of erectile dysfunction. Endocrine, 2018. 61(3): p. 372-382.

[5] Mitidieri, E., et al., Pharmacology and perspectives in erectile dysfunction in man. Pharmacol Ther, 2020. 208: p. 107493.

[6] Kenia, P.N., et al., Blockade of Toll-Like Receptor 4 Attenuates Erectile Dysfunction in Diabetic Rats. The Journal of Sexual Medicine, 2018. 15(9).

[7] Zhang, H., et al., MyD88 overexpression deteriorates Ang-II-induced ED via upregulating MPO and COX2 and downregulating eNOS in the corpus cavernosum of rats. Journal of cellular biochemistry, 2018. 120(5).

[8] Caillon, A., P. Paradis and E.L. Schiffrin, Role of immune cells in hypertension. British journal of pharmacology, 2019. 176(12).

[9] Zhang, Y., et al., Angiotensin II Silencing Alleviates Erectile Dysfunction Through Down-Regulating  the Rhoa/Rho Kinase Signaling Pathway in Rats with Diabetes Mellitus. Cell Physiol Biochem, 2018. 45(1): p. 419-427.

[10] Karakurt, D., et al., [Evaluation of the relationship between erectile dysfunction and epicardial fat tissue thickness and carotid intima-media thickness in patients with newly diagnosed hypertension]. Turk Kardiyol Dern Ars, 2020. 48(8): p. 746-753.