ijcr@oajrc.org

国际临床研究杂志

International Journal of Clinical Research

您当前位置:首页 > 精选文章

International Journal of Clinical Research. 2023; 7: (1) ; 10.12208/j.ijcr.20230001 .

The value of blood routine and C-reactive protein in pediatric influenza
血常规联合C-反应蛋白早期检测在儿童流感中的应用价值研究

作者: 张博*, 张灵妍, 胡姣, 申利彬, 格根塔娜

解放军63600部队医院儿科 甘肃兰州

*通讯作者: 张博,单位:解放军63600部队医院儿科 甘肃兰州;

引用本文: 张博, 张灵妍, 胡姣, 申利彬, 格根塔娜 血常规联合C-反应蛋白早期检测在儿童流感中的应用价值研究[J]. 国际临床研究杂志, 2023; 7: (1) : 1-3.
Published: 2023/1/13 15:46:03

摘要

目的 分析2021年冬至2022年春,某场区流感患儿发病24-48小时内血象变化,总结其变化规律,对不能行病原学检测诊断流感的基层医院提供可供参考的诊断依据,以便尽早用药治疗,避免延误病情。方法 对2021年12月至2022年4月集中出现的的一组以发热,头痛,四肢肌肉酸痛,乏力为典型症状的患儿血象进行统计分析,主要为发病24-48小时内的血象。统计病例数150例。统计其发病24-48小时内血常规白细胞计数,中性粒细胞百分、淋巴细胞百分比、C反应蛋白水平,最后进行整合和分析。结果 白细胞计数2.7~ 4.0×109/L患儿23例(15.3%),4.0~10.0×109/L患儿127例(84.7%);中性粒细胞比率75%以上患儿106例(70.6%),68%~75%患儿44例(29.4%),为4~6岁前的前,包括4~6岁的患儿,68%以下患儿0例(0%);淋巴细胞百分比在0~20%患儿148例(98.7%),20%~50%患儿2例(1.3%),50%以上患儿0例(0%)。患儿的C-反应蛋白水平为52.12±22.54(mg/L),而正常儿童C-反应蛋白水平2.14±1.05(mg/L)。结论 统计病例血象总趋势为白细胞计数正常或降低,中性粒细胞百分比明显升高,淋巴细胞百分比明显降低,C反应蛋白水平显著升高,这对不能进行病原学检测的基层单位诊断流感有较大的参考价值。

关键词: 儿童流感24-48h内血象;中性粒细胞升高;淋巴细胞抑制;基层流感诊断

Abstract

Objective: To analyze the blood changes in influenza children in some area within 24-48 hours in the spring of 2022, summarize their change rules, and provide reference diagnosis basis for basic hospitals that cannot conduct pathogen detection and diagnosis of influenza, so as to use medication as soon as possible and avoid delay in the disease.
Methods: The analysis of children from December 2021 to April 2022 was mainly within 24-48 hours. The number of statistical cases was 150. Routine blood leukocyte count, neutrophil percentage and lymphocytes within 24-48 hours of onset were counted, and finally integrated and analyzed.
Results: 23 children with 2.7~ 4.0 109 (15.3%) / L BC count, 4.0~10.0109 / L: 127 children (84.7%); Neutrophil ratio above 75% in 106 children (70.6%), 68%~75% Children 44 (29.4%), For the former years before age 4 to 6, Including children aged 4 to 6 years, There were 0 children below 68% (0%); Lymphocyte percentage in 0~20% of children in 148 patients (98.7%), Two children (1.3%) of 20%~50% children, More than 50% of the children had 0 cases (0%). The pediatric C-reactive protein level was 52.12 ± 22.54 (mg/L), while the normal pediatric C-reactive protein level was 2.14 ± 1.05 (mg/L).
Conclusion  : The general trend of statistical cases was normal or decreased leukocyte count, neutrophil percentage significantly increased, lymphocyte percentage significantly decreased, and C reactive protein level significantly increased, which has great reference value for the diagnosis of basic units for influenza.

Key words: Blood image within 24-48h of childhood influenza; Elevated neutrophils; Lymphocyte suppression; Basic diagnosis of influenza

参考文献 References

[1] 中华人民共和国国家卫生和计划生育委员会,流行性感冒诊疗方案(2018年版修订版).[2018-11-20].

[2] 陈灏珠,主编.实用内科学(上册).北京:人民卫生出版社,2007:331.

[3] Cao Bin,Li Xing-wang,Mao Yu,et al.Clini-cal Features of the Initial Cases of 2009Pan-demic Influnza  A (H1NI) Virus Infection in China.NEJM,2009,361:2507-2517.

[4] 张衡,王革非,高媛丽,等.H1NI亚流感病毒诱导外周血单个核细胞凋亡研究[J].生物化学与生物物理进展,2009,36(6):770-775.

[5] 胡吉东,吕雪霞.血常规与C反应蛋白联合用于流感儿童筛查的临床价值[J].中西医结合心血管病电子杂志,2020,8(31):88-89. 

[6] 张芳玲.C反应蛋白、血清降钙素原和血常规联合检测在儿科感染性疾病早期诊断中的临床意义[J].人人健康,2020(03):84.

[7] 崔强华,余明达,孙莉.儿童早期预警评分联合C-反应蛋白和降钙素原动态监测在小儿手足口病分流诊断及转归预测中的应用价值[J].中华实验和临床感染病杂志(电子版),2021,15(05):330-336.

[8] 黄金峰,黄媛,李雪,等.流感儿童早期血常规及C反应蛋白的特点与症状分析[J].军事医学,2019,43(08):612-615.

[9] 罗健青,陈秀芳,管敏昌,等.血常规、C-反应蛋白联合血清淀粉样蛋白A水平早期检测在儿童流感中的应用价值[J].中国卫生检验杂志,2019,29(04):432-434.

[10] 杨薇,刘小毅,陈涌泉.血清淀粉样蛋白A、C反应蛋白和血常规检测在儿童呼吸道感染早期诊断中的应用价值[J].国际医药卫生导报,2019(04):576-579.

[11] 王建忠,兰少波,黄敏敏.降钙素原、C反应蛋白、中性粒细胞、干扰素诱导蛋白10联合检测在儿童上呼吸道感染性疾病诊断中的应用价值[J].中国基层医药,2020, 27(17): 2145-2149.

[12] 邢宝宝.重症细菌感染性疾病早期诊断中血清降钙素原与C反应蛋白以及血常规联合检测的应用研究[J].中国实用医药,2019,14(03):52-54.

[13] 刘光美,陈方,于春华,等.外周血常规与C反应蛋白联合用于流感儿童筛查临床价值研究[J].临床军医杂志,2018, 46(07): 835-836.

[14] 刘凤玲,祝峰,许璐,等.降钙素原、C反应蛋白及血常规对77例早期细菌感染的联合检测[J].武警医学,2018, 29(03): 299-300.

[15] 张延,李丽玮,乔立冬.血清降钙素原、C反应蛋白及血常规联合检测在重症细菌感染性疾病早期诊断中的应用[J].贵州医药,2018,42(01):96-97.