To investigate the distribution pattens of diurnal intraocular pressure in primary open angle glaucoma and ocular hypertension patientsby the midnight-noon ebb-flow theory
通过子午流注理论探讨原发性开角型青光眼及高眼压症患者昼夜眼压的波动规律

摘要

目的 通过24小时眼压监测并依据子午流注理论探讨原发性开角型青光眼（POAG）和高眼压症（OHT）患者的眼压分布规律。方法 回顾分析2019.01-2021.01于我院完成24小时眼压监测的103例患者（206眼），根据眼压，视神经OCT，视野及UBM等结果，将患者分为POAG组63例（126眼）和OHT组40例（80眼），并依据十二时辰统计分析两组患者眼压波动规律。结果 两组患者平均眼压到达峰值的时间不同，OHT组平均眼压为辰时[7:00-9:00）达到最高峰，为21.69±4.99mmHg，而POAG组平均眼压为午时 [11:00-13:00）达到最高峰，为19.84±5.36mmHg。OHT组稍高于POAG组，但二者差异无明显统计学意义（p＞0.05）。从日间眼压的波动来看：POAG组（10.06±3.670 mmHg）略低于OHT组（11.11±3.493 mmHg），但差异未见统计学意义（p＞0.05）。结论 POAG组与OHT组相比，平均眼压到达峰值的时间不同，提示眼压节律的改变可能也是青光眼发病机制中的重要一环。

Abstract

Objective: To investigate the distribution patten of intraocular pressure in primary open angle glaucoma (POAG) and ocular hypertension (OHT) by 24 hours monitoring according to the midnight-noon ebb-flow theory.
Methods: A retrospective analysis was performed on 103 patients (206 eyes) hospitalized in Guangdong Hospital of Traditional Chinese Medicine from January 2019 to January 2021, who accomplished a completed 24-hour intraocular pressure monitoring. According to the results of 24-hour intraocular pressure monitoring, optic nerve OCT, visual field and UBM, the patients were divided into 2 groups: POAG group, 63 patients (126 eyes) and OHT group, 40 cases (80 eyes). The distribution patten of intraocular pressure in both groups was analyzed based on twelve-shichen theory in Chinese traditional medicine.
Results: The average IOP of the two groups peaked in different time point. The average IOP of the OHT group peaked at Chen-shi [7:00-9:00], 21.69±4.99mmHg, while that of the POAG group peaked at Wu-shi [11:00-13:00]. The mean peak IOP in OHT group was slightly higher than that in POAG group, but the difference was not statistically significant(p＞0.05). According to the fluctuation of diurnal IOP: the intraocular pressure fluctuation in POAG group (10.06±3.670 mmHg) slightly lower than OHT group (11.11±3.493 mmHg), however, there was no significant difference between POAG group and OHT group(p＞0.05).
Conclusion  : The peak time of IOP between the POAG group was different, suggesting that the change of IOP rhythm may be an important part of the pathogenesis of glaucoma.