Analysis of the diagnostic effect and detection rate of print sheet cytology and combined rapid immunohistochemical detection in the sentinel lymph node biopsy of breast cancer
印片细胞学联合快速免疫组化检测在乳腺癌前哨淋巴结活检术中诊断的效果及检出率分析

摘要

目的 探究乳腺癌前哨淋巴结活检术中应用印片细胞学（TIC）联合快速免疫组化（RIHC）检测的价值。方法 选择本院内行乳腺癌前哨淋巴结活检术的患者进行研究，共计收治了114例患者，样本纳入时间为2020年7月至2022年4月。本院于术中开展TIC、RIHC单一与联合检测，并于术后开展石蜡切片检测。以术后石蜡切片检测结果为金标准，分析单一检测与联合检测的灵敏度、特异度、准确度、阳性预测值、阴性预测值。结果 经术后石蜡切片检测，纳入患者发生前哨淋巴结转移者57例，阳性率50%。TIC检测诊出阳性38例，RIHC检测诊出阳性39例，联合检测诊出阳性56例，联合检测灵敏度、准确度高于单一检测（P<0.05）。结论 在乳腺癌前哨淋巴结活检术中应用TIC、RIHC联合诊断效果显著，疾病诊出率、诊断准确性均优于单一检测。

Abstract

Objective: To explore the value of applying print cytology (TIC) combined with rapid immunohistochemistry (RIHC) detection in the sentinel lymph node biopsy of breast cancer.
Methods Patients undergoing sentinel lymph node biopsy for breast cancer were selected for the study. A total of 114 patients were admitted from July 2020 to April 2022. The hospital carried out intraoperative single and combined tests of TIC and RIHC, and performed postoperative paraffin section testing. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of a single test and a combined test were analyzed by using the test results of postoperative paraffin sections as the gold standard.
Results After postoperative paraffin sections, 57 patients developed sentinel lymph node metastasis, with a 50% positive rate. Thirty-eight cases were positive by TIC, 39 cases were positive by RIHC, and 56 cases were positive by combination test. The sensitivity of combination test and accuracy was higher than that of single test (P <0.05).
Conclusion   The combination of TIC and RIHC in the sentinel lymph node biopsy of breast cancer is remarkable, and the disease diagnosis rate and diagnostic accuracy is better than a single test.