Clinical Observation of AcupointCatgut Embedding Therapy for Diuretic Resistance in Chronic HeartFailure and the Influence of AQP2 Expression
穴位埋线治疗慢性心衰利尿剂抵抗临床观察及AQP2表达的影响

摘要

目的 观察穴位埋线治疗心力衰竭患者利尿剂抵抗的临床疗效，NT‐pro BNP及AQP2表达的影响。方法 选取慢性心力衰竭利尿剂抵抗患者64例，随机分为治疗组与对照组。两组均接受西医常规治疗，治疗组给予西医常规治疗加穴位埋线治疗；连续治疗10d后比较两组患者的临床疗效、24h尿量及血浆氨基末端脑钠肽前体（NT-pro BNP）水平及AQP2表达的变化。结果 治疗后，治疗组治疗有效率高于对照组, 差异有统计学意义（P<0.05）。2组患者24h尿量均较治疗前明显增加，差异均具有统计学意义（P<0.05）。治疗组NT‐pro BNP水平、AQP2值较治疗前降低，差异均具有统计学意义（P<0.05）；但对照组虽然比值有所下降，但差异无统计学意义（P>0.05）。结论 对于心衰利尿剂抵抗患者的治疗，采用穴位埋线疗法临床疗效显著，能有效改善症状，促进排尿，改善利尿剂抵抗，提高临床疗效。

Abstract

Objective To observe the clinical effect of acupoint catgut embedding on diuretic resistance in patients with heart failure, and the influence of NT‐pro BNP and AQP2 expression.
Methods 64 patients with diuretic resistance in chronic heart failure were randomly divided into treatment group and control group. Both groups received routine western medicine treatment, while the treatment group received routine western medicine treatment plus acupoint catgut embedding treatment. Clinical efficacy, 24-hour urine volume, plasma N-terminal pro-brain natriuretic peptide (NT-pro BNP) level and AQP2 expression were compared between the two groups after 10 days of continuous treatment.
Results: After treatment, the effective rate of the treatment group was higher than that of the control group, and the difference was statistically significant (P < 0.05). The 24-hour urine output of the two groups was significantly higher than that before treatment, and the difference was statistically significant (P<0.05). The levels of NT‐pro BNP and AQP2 in the treatment group were lower than those before treatment, and the differences were statistically significant (P < 0.05). However, although the ratio of the control group decreased, the difference was not statistically significant (P>0.05).
Conclusion  : For the treatment of heart failure patients with diuretic resistance, acupoint catgut embedding therapy has a significant clinical effect, which can effectively improve symptoms, promote urination, improve diuretic resistance and improve clinical efficacy.