International Journal of Clinical Research
International Journal of Clinical Research. 2022; 6: (10) ; 10.12208/j.ijcr.20220474 .
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青岛市黄岛区中心医院肿瘤科 山东青岛
*通讯作者： 崔雯,单位：青岛市黄岛区中心医院肿瘤科 山东青岛；
目的 回顾性分析帕洛诺司琼联合地塞米松在预防胃癌化疗中奥沙利铂所致恶心、呕吐的疗效观察。方法 选择2020年1月～2022年1月在黄岛区中心医院诊治的胃癌患者32例，均应用含奥沙利铂的化疗方案，其中观察组16列，对照组16例。观察组化疗前30分钟应用帕洛诺司琼，对照组化疗前30分钟应用托烷司琼，两组均于化疗前第1天、化疗后第2、3天静脉应用地塞米松。结果 两组患者在急性期的呕吐完全缓解率差异无统计学意义（P>0.05），但在延迟期和全期差异均有统计学意义（P<0.05）。结论 帕洛诺司琼联合地塞米松防治胃癌化疗中奥沙利铂所导致的延迟期及全期的恶心呕吐的疗效优于托烷司琼。
Objective To retrospectively analyze the Effect of Polonosetron Plus Dexamethasone in Preventing Oxaliplatin-Based Chemotherapy induced Nausea and Vomiting in Gastric Cancer. Methods 32 patients with gastric cancertreated in the Huangdao Central Hospital from January 2020 to January 2022 were enrolled in this trial, through Oxaliplatin-Based Chemotherapy.16 cases（the observation group)received plalonosetron before 30 min administration of oxaliplatin.16 cases（the controlgroup) received tolansetronbefore 30 min administration of oxaliplatin. Dexamethasone was given intravenously on day 1 before chemotherapy and day 2 and 3 after chemotherapy in the two groups. Results There was no statistically significant difference in the complete remission rate of vomiting between 2 groups in the acute phase (P>0.05), but there was statistically significant difference in the delayed phase and the whole phase (P<0.05). Conclusion The efficacy of palonosetron combined with dexamethasone in the treatment of delayed phase and whole phase nausea and vomiting induced by oxaliplatin in gastric cancer chemotherapy is better than that of tolansetron.
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