Clinical efficacy of mifepristone combined with methotrexate in conservative treatment of ectopic pregnancy
米非司酮联合甲氨蝶呤对宫外孕保守治疗的临床疗效研究

摘要

要】目的 探究宫外孕使用米非司酮、甲氨蝶呤两项药物保守治疗效果。方法 研究患者选取时间2021年2月到2022年7月，共60例，随机分组，即研究组、对照组，每组30，分析两组疗效。结果 研究组宫外孕患者D二聚体和体重指数水平更稳定，腹部包块、腹痛、阴道流血症状恢复时间以及血HCG转阴时间更快；药物治疗后，研究组宫外孕患者孕酮值明显下降、腹部包块直径、CA125水评和血HCG值均低于对照组；研究组不良反应发生率与对照组相比明显更低，P值＜0.05。结论 宫外孕联合保守用药疗效明显高于单一用药，服药后患者症状消退时间快、不良反应少，药物安全性高。

Abstract

Objective: To explore the effect of conservative treatment of ectopic pregnancy with mifepristone and methotrexate.
Methods: 60 patients were selected from February 2021 to July 2022. They were randomly divided into study group and control group, with 30 patients in each group. The efficacy of the two groups was analyzed.
Results: in the study group, the levels of D-dimer and body mass index were more stable, the recovery time of abdominal mass, abdominal pain, vaginal bleeding and the time of blood HCG turning negative were faster; After drug treatment, the progesterone value, abdominal mass diameter, CA125 water evaluation and blood HCG value of patients with ectopic pregnancy in the study group were significantly lower than those in the control group; The incidence of adverse reactions in the study group was significantly lower than that in the control group (P < 0.05); The rate of normal intrauterine pregnancy (22 cases / 73.33%) in the study group was significantly higher than that in the control group, and the overall fertility outcome was better than that in the control group (P < 0.05).
Conclusion  : the efficacy of ectopic pregnancy combined with conservative medicine is significantly higher than that of single medicine. After taking medicine, the symptoms of patients subside quickly, the adverse reactions are less, and the drug safety is high.