Effects of azithromycin administration on reducing the incidence of adverse reactions in children
阿奇霉素不同给药方式对降低患儿不良反应发生率的影响

摘要

目的 探究阿奇霉素给药方式不同对患儿用药不良反应的影响。方法 选取时间 2021 年 2 月到 2022 年 4 月，选自院内急诊科，共 60 人，年龄均小于 12 岁，根据阿奇霉素给药方式的不同分成研究组和 对照组，每组小儿平均 30 人，比对患儿不良反应情况。结果 研究组患儿三项血清炎症因子指标明显下降， 显著低于对照组；研究组用药不良反应发生率为 10.00%，显著低于对照组；研究组患儿住院时长、病症和 体征改善时间均短于对照组，P 值＜0.05；研究组治疗显效 20 例、有效 8 例，总有效率显著高于对照组（P ＜0.05），患儿用药后并未出现重度不良反应。结论 小儿使用阿奇霉素时选择口服给药方式，用药后不良 反应更轻，发生率更低，临床治疗效果更显著。

Abstract

Objective To explore the effects of different administration methods of azithromycin on adverse drug reactions in children.
Methods A total of 60 patients, all younger than 12 years old, were selected from the emergency department of our hospital from February 2021 to April 2022. They were divided into study group and control group according to different azithromycin administration methods, with an average of 30 children in each group, and the adverse reactions of the children were compared.
Results Three serum inflammatory factors in the study group were significantly lower than those in the control group. The incidence of adr in the study group was 10.00%, significantly lower than that in the control group. The length of hospitalization and improvement time of symptoms and signs in the study group were shorter than those in the control group (P < 0.05). The total effective rate in the study group was significantly higher than that in the control group (P < 0.05). There were no severe adverse reactions after treatment.
Conclusion   Oral administration of azithromycin in children has less adverse reactions, lower incidence, and more significant clinical treatment effect.