The role of biochemical test indexes in early diagnosis of diabetic nephropathy
生化检验指标在糖尿病肾病早期诊断中的作用

摘要

目的 探究糖尿病肾病早期诊断中应用生化检验指标诊断的效果。方法 选择本院内分泌科收治的早期糖尿病肾病患者作为研究对象（观察组），共计80例，收治时间为2020年1月至2021年12月，并择取同期本院体检的健康人士80例作为参照对象（对照组）。本院对纳入对象均行生化检验，同时对观察组患者另行尿常规检验。分析两种检验方式的疾病检出率，比较两组对象生化指标水平差异。结果 生化检验疾病诊出率高于尿常规检验（P<0.05）。观察组对象尿视黄醇结合蛋白（Retinol-Binding Protein,RBP）、β2-微球蛋白（β2-Micro globulin，β2-MG）、尿微量白蛋白（Micro-albumin urine，MAU）、尿免疫球蛋白（immunoglobulin，Ig）、C反应蛋白（C-reactive protein，CRP）、血清胱抑素（Cystatin C，CysC）、糖化血红蛋白（glycosylated hemoglobin，HbAlc）、血肌酐（Serum creatinine，Cr）水平均高于对照组（P<0.05）。结论 糖尿病肾病患者机体生化指标水平会发生显著改变，生化检验指标诊断疾病准确性高，值得推广。

Abstract

Objective To explore the effect of biochemical test indicators in the early diagnosis of diabetic nephropathy.
Methods A total of 80 patients with early diabetic nephropathy admitted to the Endocrinology Department of our hospital were selected as the research subjects (observation group), and the treatment time was from January 2020 to December 2021, and 80 healthy people who underwent physical examination in our hospital during the same period were selected as the research subjects (observation group). Reference object (control group). Biochemical tests were performed on the included subjects in our hospital, and urine routine tests were also performed on the patients in the observation group. The disease detection rates of the two testing methods were analyzed, and the differences in the levels of biochemical indexes were compared between the two groups.
Results The diagnosis rate of biochemical test was higher than that of urine routine test (P<0.05). The subjects in the observation group were urine retinol-binding protein (Retinol-Binding Protein, RBP), β2-microglobulin (β2-Micro globulin, β2-MG), urine microalbumin (Micro-albumin urine, MAU), urine immunoglobulin Protein (immunoglobulin, Ig), C-reactive protein (C-reactive protein, CRP), serum cystatin (Cystatin C, CysC), glycosylated hemoglobin (glycosylated hemoglobin, HbAlc), serum creatinine (Serum creatinine, Cr) levels were all high in the control group (P<0.05).
Conclusion   The levels of biochemical indexes in patients with diabetic nephropathy will change significantly, and the biochemical test indexes have high accuracy in diagnosing the disease and are worthy of promotion.