Effect of phentolamine combined with kalosulfonate in the treatment of bronchiectasis with hemoptysis
酚妥拉明联合卡络磺钠治疗支气管扩张伴咯血的效果

摘要

目的 观察酚妥拉明联合卡络磺钠治疗支气管扩张伴咯血的效果。方法 将2019年11月-2021年11月期间接收的200例支气管扩张伴咯血患者纳入研究，用双盲法随机分成试验组与参照组，每组100例。两组患者均接受基础治疗，在药物治疗上，参照组用卡络磺钠，试验组用酚妥拉明联合卡络磺钠，对比两组咯血量、咯血消失时长与治疗前后肺功能指标[第一秒用力呼气容积（FEV1）、用力肺活量（FVC）、FEV1/FVC]以及不良反应产生指数。结果 试验组咯血量低于参照组，咯血消失时长短于参照组，有统计学差异（P＜0.05）；治疗前，两组患者的肺功能指标均无统计学差异（P＞0.05），治疗后，两组患者的肺功能指标均明显改善，其中试验组FEV1、FVC、FEV1/FVC均高于参照组，有统计学差异（P＜0.05）；两组不良反应产生指数无统计学差异（P＞0.05）。结论 酚妥拉明联合卡络磺钠治疗支气管扩张伴咯血有显著效果，有利于加速咯血症状消失，帮助肺功能恢复，同时不提高不良反应产生风险。

Abstract

Objective: To observe the effect of phentolamine combined with kalosulfonate in the treatment of bronchiectasis with hemoptysis.
Methods: 200 patients with bronchiectasis and hemoptysis received from November 2019 to November 2021 were included in the study. They were randomly divided into experimental group and reference group by double-blind method, with 100 cases in each group. The patients in both groups received basic treatment. In terms of drug treatment, the reference group was treated with carbosulfan sodium, and the experimental group was treated with phentolamine combined with carbosulfan sodium. The volume of hemoptysis, the length of hemoptysis disappearance, pulmonary function indexes before and after treatment (FEV1, FVC, fev1/fvc) and adverse reaction generation index were compared between the two groups.
Results: the amount of hemoptysis in the experimental group was lower than that in the reference group, and the length of hemoptysis disappearance was shorter than that in the reference group, with statistical difference (P < 0.05); Before treatment, there was no statistical difference in pulmonary function indexes between the two groups (P > 0.05). After treatment, the pulmonary function indexes of the two groups were significantly improved, in which FEV1, FVC and fev1/fvc in the experimental group were higher than those in the reference group, with statistical difference (P < 0.05); There was no significant difference in the adverse reaction index between the two groups (P > 0.05).
Conclusion  : phentolamine combined with kalosulfonate has a significant effect in the treatment of bronchiectasis with hemoptysis, which is beneficial to accelerate the disappearance of hemoptysis symptoms, help the recovery of lung function, and do not increase the risk of adverse reactions.