International Journal of Clinical Research
International Journal of Clinical Research. 2022; 6: (8) ; 10.12208/j.ijcr.20220354 .
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西安医学院 陕西西安
*通讯作者： 刘凯歌,单位：西安医学院 陕西西安；
微血栓的形成与一系列不同的疾病相关，包括内皮功能损伤、血管活性异常，最终会形成微血栓而造成组织损伤和器官功能障碍。微血栓常出现在小静脉、毛细血管及微循环中，多种疾病均会出现微血栓这类血栓前状态，具体形成机制仍在探索中。研究人体的心脏、肺脏以及肾脏中的一系列微血管疾病之间的关系可能会发现共同的机制，目前认为微血栓的出现可能是血管收缩障碍、免疫效应降低的原因。本综述将探讨出现微血栓患者的各种血液学事件、发病机制、与不良结局相关的生物标志物以及治疗方法。
The formation of microthrombus is related to a series of different diseases, including endothelial function damage, abnormal vascular activity, and eventually microthrombus resulting in tissue damage and organ dysfunction. Microthrombosis often occurs in venules, capillaries and microcirculation. Prethrombotic states such as microthrombosis occur in many diseases, and the specific formation mechanism is still being explored. The common mechanism may be found by studying the relationship among a series of microvascular diseases in human heart, lung and kidney. at present, it is believed that the emergence of microthrombus may be the cause of vasoconstriction disorder and decreased immune effect. Thisreview will explore various hematological events, pathogenesis, biomarkers associated with adverse outcomes, and treatments in patients with emerging microthrombosis.
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