International Journal of Clinical Research
International Journal of Clinical Research. 2022; 6: (8) ; 10.12208/j.ijcr.20220347 .
总浏览量: 409
南昌大学第四附属医院 江西南昌
*通讯作者： 楼小亮,单位：南昌大学第四附属医院 江西南昌；
目的 本文探究对老年痴呆患者实施尼莫地平+多奈哌齐进行治疗，其临床治疗效果。方法 此次选取我院在2019年12月-2022年5月期间进行治疗的98例老年痴呆患者作为研究对象，对比两组患者治疗效果和生活质量、词汇记忆评分以及不良反应发生情况。结果 联合用药治疗组治疗效果、生活质量、词汇记忆评分均优于多奈哌齐治疗组，P＜0.05说明存在对比意义，而不良反应发生率无显著变化，P＞0.05说明不存在对比意义。结论 对老年痴呆患者采取尼莫地平+多奈哌齐联合治疗，其治疗效果显著，说明该治疗方案具有较高的临床价值。
Objective: To explore the clinical effect of nimodipine + donepezil in the treatment of senile dementia. Methods: 98 patients with Alzheimer's disease who were treated in our hospital from December 2019 to may 2022 were selected as the study subjects to compare the treatment effect, quality of life and vocabulary memory score of the two groups of patients. Results: the treatment effect, quality of life and vocabulary memory score of the combined drug treatment group were better than that of the donepezil treatment group (P < 0.05), indicating that there was a comparative significance, while the incidence of adverse reactions had no significant change (P > 0.05), indicating that there was no comparative significance. Conclusion : the combination of nimodipine and donepezil is effective in the treatment of senile dementia, which indicates that the treatment scheme has high clinical value.
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