Effect of intravenous infusion time of azithromycin on the treatment effect and safety of children with Mycoplasma pneumoniae pneumonia
阿奇霉素静脉滴注时间对肺炎支原体肺炎患儿治疗效果及安全性的影响

摘要

肺炎支原体肺炎主要是指由肺炎支原体感染引起的肺部炎症[1]。流行病学显示该病发病患者年龄偏低，以儿童及青年人居多，常表现为呼吸困难、咳嗽、疲乏、运动耐量下降、发热及头痛等[2]。肺炎支原体肺炎大多症状较轻，但儿童患者由于免疫力低下，呼吸道管腔狭窄，易引发多种并发症如肺不张、心肌损害、肝功损害等，严重影响患儿的生活质量，甚至危及其生命健康，应引起临床重视[3]。目前临床上常早期应用大环内酯类如阿奇霉素通过阻碍肺炎支原体转肽过程抑制其蛋白质合成从而减轻肺炎支原体肺炎患儿症状，缩短病程[4]。但当前多数医护人员对阿奇霉素治疗肺炎支原体肺炎患儿静脉滴注时间尚有异议，为进一步研究阿奇霉素不同静脉滴注时间对肺炎支原体肺炎患儿治疗效果及安全性的影响，本研究选择180例于本院儿内科治疗的肺炎支原体肺炎患儿作为观察对象，报道如下。

Abstract

Mycoplasma pneumoniae pneumonia refers primarily to inflammation of the lungs caused by Mycoplasma pneumoniae infection[1]. Epidemiology shows that the onset of the disease is low in age, mostly in children and young people, and often presents with dyspnea, cough, fatigue, decreased exercise tolerance, fever, and headache [2]. Most of the symptoms of Mycoplasma pneumoniae pneumonia are mild, but due to low immunity and narrowing of the respiratory lumen, pediatric patients are prone to a variety of complications such as atelectasis, myocardial damage, liver function damage, etc., which seriously affect the quality of life of children, and even endanger their life and health, which should arouse clinical attention [3]. At present, macrolides such as azithromycin are often used early in clinical practice to inhibit protein synthesis by obstructing the transpeptide process of Mycoplasma pneumoniae, thereby alleviating symptoms and shortening the course of disease in children with Mycoplasma pneumoniae pneumonia [4]. However, at present, most medical staff still have objections to the time of intravenous infusion of azithromycin in children with Mycoplasma pneumoniae pneumonia, in order to further study the effect and safety of different intravenous infusion times of azithromycin on the treatment effect and safety of children with Mycoplasma pneumoniae pneumonia, this study selected 180 cases of children with Mycoplasma pneumoniae treated in the pediatric department of this hospital as observation objects, the report is as follows.