ijcr@oajrc.org
您当前位置:首页 > 精选文章

International Journal of Clinical Research. 2021; 5: (4) ; 10.12208/j.ijcr.20210034 .

TheValue of carotid ultrasound plaque characteristics in the evaluation of coronary atherosclerotic disease
颈动脉超声斑块特征对冠状动脉粥样硬化性疾病的评估价值

作者: 包鑫, 张正义*,

兰州大学第二医院全科医学科 甘肃兰州

*通讯作者: 张正义,单位:兰州大学第二医院全科医学科 甘肃兰州;

引用本文: 张正义*,. 颈动脉超声斑块特征对冠状动脉粥样硬化性疾病的评估价值[J]. 国际临床研究杂志, 2021; 5: (4) : 24-31.
Published: 2021/11/11 15:44:04

摘要

冠状动脉粥样硬化性疾病(CAD)的发病率和死亡率在世界范围内逐年增加。早期发现、预防高危CAD,尤其是不典型患者,对减少心血管相关疾病死亡率、致残率至关重要。颈动脉超声是检测临床动脉粥样硬化和识别CAD的一种无创且敏感的筛查方法。常用的评估指标有颈动脉内膜中层厚度、斑块厚度、斑块积分、斑块长度、斑块面积等已被证明与 CAD 相关,但目前关于哪种颈动脉超声参数是CAD的最佳评估指标尚未达成共识。本文将对颈动脉斑块特征对CAD评估价值的研究进展做一综述。

关键词: 冠状动脉粥样硬化性疾病;颈动脉内膜中层厚度;颈动脉斑块

Abstract

The incidence and mortality of coronary atherosclerotic disease (CAD) is increasing year by year worldwide. Early detection and prevention of CAD, especially in atypical patients, is essential to reduce cardiovascular-related death. Carotid ultrasound is a noninvasive and sensitive screening method for detecting subclinical atherosclerosis and identifying CAD. Commonly used evaluation indicators include carotid intima-media thickness, plaque thickness, plaque score, plaque lengthandplaque areahave been shown to be associated with CAD, but there is no consensus on which carotid ultrasound parameter is the best evaluation indicator of CAD. This article will review the research progress on the value of carotid plaque characteristics in the evaluation of CAD.

Key words: Coronary Atherosclerotic Disease; Carotid Intima-Media Thickness; Carotid Plaque

参考文献 References

[1] ROTH G A, HUFFMAN M D, MORAN A E, et al. Global and regional patterns in cardiovascular mortality from 1990 to 2013 [J]. Circulation, 2015, 132(17): 1667-78.

[2] TEN KATE G L, TEN KATE G J, VAN DEN OORD S C, et al. Carotid plaque burden as a measure of subclinical coronary artery disease in patients with heterozygous familial hypercholesterolemia [J]. The American journal of cardiology, 2013, 111(9): 1305-10.

[3] JEEVARETHINAM A, VENURAJU S, WEYMOUTH M, et al. Carotid intimal thickness and plaque predict prevalence and severity of coronary atherosclerosis: a pilot study [J]. Angiology, 2015, 66(1): 65-9.

[4] JAMTHIKAR A D, GUPTA D, PUVVULA A, et al. Cardiovascular risk assessment in patients with rheumatoid arthritis using carotid ultrasound B-mode imaging [J]. Rheumatol Int, 2020, 40(12): 1921-39.

[5] YEBOAH J, MCCLELLAND R L, POLONSKY T S, et al. Comparison of novel risk markers for improvement in cardiovascular risk assessment in intermediate-risk individuals [J]. JAMA, 2012, 308(8): 788-95.

[6] PARK H W, KIM W H, KIM K H, et al. Carotid plaque is associated with increased cardiac mortality in patients with coronary artery disease [J]. International journal of cardiology, 2013, 166(3): 658-63.

[7] IKEDA N, KOGAME N, IIJIMA R, et al. Carotid artery intima-media thickness and plaque score can predict the SYNTAX score [J]. European heart journal, 2012, 33(1): 113-9.

[8] WU N, CHEN X, LI M, et al. Predicting obstructive coronary artery disease using carotid ultrasound parameters: A nomogram from a large real-world clinical data [J]. European journal of clinical investigation, 2018, 48(8): e12956.

[9] DE KORTE C, FEKKES S, NEDERVEEN A, et al. Review: Mechanical Characterization of Carotid Arteries and Atherosclerotic Plaques [J]. 2016, 63(10): 1613-23.

[10] ALIZARGAR J, BAI C H. Factors associated with carotid Intima media thickness and carotid plaque score in community-dwelling and non-diabetic individuals [J]. BMC Cardiovasc Disord, 2018, 18(1): 21.

[11] NABA Y, CHEN J A, BERGMANN S R. Carotid plaque, compared with carotid intima-media thickness, more accurately predicts coronary artery disease events: a meta-analysis [J]. Atherosclerosis, 2012, 220(1): 128-33.

[12] KOZLOV S, BALACHONOVA T, MACHMUDOVA H, et al. Carotid atherosclerosis, endothelial disfunction, and arterial stiffness in young and middle-aged men with coronary artery disease [J]. International journal of vascular medicine, 2012, 2012(950130.

[13] GRUBIC N, COLLEDANCHISE K N, LIBLIK K, et al. The Role of Carotid and Femoral Plaque Burden in the Diagnosis of Coronary Artery Disease [J]. Curr Cardiol Rep, 2020, 22(10): 121.

[14] PARASKEVAS K I, SILLESEN H H, RUNDEK T, et al. Carotid Intima-Media Thickness Versus Carotid Plaque Burden for Predicting Cardiovascular Risk [J]. Angiology, 2020, 71(2): 108-11.

[15] CAO X, ZHANG J, GENG D. Use of oral anticoagulant drugs is associated with carotid intraplaque hemorrhage in atherosclerosis patients: a meta-analysis [J]. J Thromb Thrombolysis, 2019, 48(1): 68-76.

[16] TSCHIDERER L, KLINGENSCHMID G, SEEKIRCHER L, et al. Carotid intima-media thickness predicts carotid plaque development: Meta-analysis of seven studies involving 9341 participants [J]. Eur J Clin Invest, 2020, 50(4): e13217.

[17] AMATO M, VEGLIA F, DE FAIRE U, et al. Carotid plaque-thickness and common carotid IMT show additive value in cardiovascular risk prediction and reclassification [J]. 2017, 263(412-9.

[18] TOUBOUL P J, HENNERICI M G, MEAIRS S, et al. Mannheim carotid intima-media thickness and plaque consensus (2004-2006-2011). An update on behalf of the advisory board of the 3rd, 4th and 5th watching the risk symposia, at the 13th, 15th and 20th European Stroke Conferences, Mannheim, Germany, 2004, Brussels, Belgium, 2006, and Hamburg, Germany, 2011 [J]. Cerebrovascular diseases (Basel, Switzerland), 2012, 34(4): 290-6.

[19] CHUNG H, KIM B Y, KIM H S, et al. Long-Term Clinical Effects of Carotid Intraplaque Neovascularization in Patients with Coronary Artery Disease [J]. Korean J Radiol, 2020, 21(7): 900-7.

[20] RUNDEK T, ARIF H, BODEN-ALBALA B, et al. Carotid plaque, a subclinical precursor of vascular events: the Northern Manhattan Study [J]. 2008, 70(14): 1200-7.

[21] SILLESEN H, SARTORI S, SANDHOLT B, et al. Carotid plaque thickness and carotid plaque burden predict future cardiovascular events in asymptomatic adult Americans [J]. European heart journal cardiovascular Imaging, 2018, 19(9): 1042-50.

[22] LEBLANC S, BIBEAU K, BERTRAND O, et al. Carotid versus coronary atherosclerosis burdens in acute compared with chronic symptomatic coronary artery disease [J]. 2017, 95(8): 878-87.

[23] MATHIESEN E B, JOHNSEN S H, WILSGAARD T, et al. Carotid plaque area and intima-media thickness in prediction of first-ever ischemic stroke: a 10-year follow-up of 6584 men and women: the Tromsø Study [J]. Stroke, 2011, 42(4): 972-8.

[24] JOHRI A M, LAJKOSZ K A, GRUBIC N, et al. Maximum plaque height in carotid ultrasound predicts cardiovascular disease outcomes: a population-based validation study of the American society of echocardiography's grade II-III plaque characterization and protocol [J]. Int J Cardiovasc Imaging, 2021, 

[25] ADAMS A, BOJARA W, SCHUNK K. Early Diagnosis and Treatment of Coronary Heart Disease in Asymptomatic Subjects With Advanced Vascular Atherosclerosis of the Carotid Artery (Type III and IV b Findings Using Ultrasound) and Risk Factors [J]. Cardiology research, 2018, 9(1): 22-7.

[26] AKAZAWA S, TOJIKUBO M, NAKANO Y, et al. Usefulness of carotid plaque (sum and maximum of plaque thickness) in combination with intima-media thickness for the detection of coronary artery disease in asymptomatic patients with diabetes [J]. J Diabetes Investig, 2016, 7(3): 396-403.

[27] CEPONIENE I, LI D, EL KHOUDARY S R, et al. Association of Coronary Calcium, Carotid Wall Thickness, and Carotid Plaque Progression With Low-Density Lipoprotein and High-Density Lipoprotein Particle Concentration Measured by Ion Mobility (From Multiethnic Study of Atherosclerosis [MESA]) [J]. Am J Cardiol, 2021, 142(52-8.

[28] KHANNA N N, JAMTHIKAR A D, GUPTA D, et al. Effect of carotid image-based phenotypes on cardiovascular risk calculator: AECRS1.0 [J]. Med Biol Eng Comput, 2019, 57(7): 1553-66.

[29] LEE S W, KIM H C, LEE Y H, et al. Association between HbA1c and carotid atherosclerosis among elderly Koreans with normal fasting glucose [J]. PloS one, 2017, 12(2): e0171761.

[30] COLLEDANCHISE K N, MANTELLA L E, BULLEN M, et al. Combined Femoral and Carotid Plaque Burden Identifies Obstructive Coronary Artery Disease in Women [J]. J Am Soc Echocardiogr, 2020, 33(1): 90-100.

[31] CROCA S C, GRIFFIN M, FARINHA F, et al. Total plaque area and plaque echogenicity are novel measures of subclinical atherosclerosis in patients with systemic lupus erythematosus [J]. Rheumatology (Oxford), 2021, 

[32] IMAHORI Y, MATHIESEN E B, MORGAN K E, et al. The association between anthropometric measures of adiposity and the progression of carotid atherosclerosis [J]. BMC Cardiovasc Disord, 2020, 20(1): 138.

[33] ELHFNAWY A M, VOLKMANN J, SCHLIESSER M, et al. Symptomatic vs. Asymptomatic 20-40% Internal Carotid Artery Stenosis: Does the Plaque Size Matter? [J]. Front Neurol, 2019, 10(960.

[34] NICOLAIDES A N, KAKKOS S K, KYRIACOU E, et al. Asymptomatic internal carotid artery stenosis and cerebrovascular risk stratification [J]. Journal of vascular surgery, 2010, 52(6): 1486-96.e1-5.

[35] FINN A V, KOLODGIE F D, VIRMANI R. Correlation between carotid intimal/medial thickness and atherosclerosis: a point of view from pathology [J]. Arterioscler Thromb Vasc Biol, 2010, 30(2): 177-81.

[36] TANG W, SHEN X, LI H, et al. The independent and incremental value of ultrasound carotid plaque length to predict the presence and severity of coronary artery disease: analysis from the carotid plaque length prospective registry [J]. Eur Heart J Cardiovasc Imaging, 2020, 21(4): 389-96.

[37] SELWANESS M, BOS D, VAN DEN BOUWHUIJSEN Q, et al. Carotid Atherosclerotic Plaque Characteristics on Magnetic Resonance Imaging Relate With History of Stroke and Coronary Heart Disease [J]. 2016, 47(6): 1542-7.

[38] NONIN S, IWATA S, SUGIOKA K, et al. Plaque surface irregularity and calcification length within carotid plaque predict secondary events in patients with coronary artery disease [J]. Atherosclerosis, 2017, 256(29-34.

[39] BABANIAMANSOUR P, MOHAMMADI M, BABANIAMANSOUR S, et al. The Relation between Atherosclerosis Plaque Composition and Plaque Rupture [J]. J Med Signals Sens, 2020, 10(4): 267-73.

[40] MANTELLA L E, COLLEDANCHISE K N, HETU M F, et al. Carotid intraplaque neovascularization predicts coronary artery disease and cardiovascular events [J]. Eur Heart J Cardiovasc Imaging, 2019, 20(11): 1239-47.

[41] SONG Y, DANG Y, WANG J, et al. Carotid Intraplaque Neovascularization Predicts Ischemic Stroke Recurrence in Patients with Carotid Atherosclerosis [J]. Gerontology, 2021, 1-8.

[42] SARDELI A V, GASPARI A F, DE ROSSI G, et al. Carotid intima-media thickness is associated with media rather than intima thickness [J]. Atherosclerosis, 2017, 261(169-71.

[43] JAMTHIKAR A D, GUPTA D, MANTELLA L E, et al. Multiclass machine learning vs. conventional calculators for stroke/CVD risk assessment using carotid plaque predictors with coronary angiography scores as gold standard: a 500 participants study [J]. Int J Cardiovasc Imaging, 2020, 

[44] JAMTHIKAR A D, GUPTA D, SABA L, et al. Artificial intelligence framework for predictive cardiovascular and stroke risk assessment models: A narrative review of integrated approaches using carotid ultrasound [J]. Comput Biol Med, 2020, 126(104043.