Objective: To explore the clinical effect of copper span scraping therapy in relieving anxiety and depression symptoms in patients with depression. Methods: Ninety-six inpatients with mental disorders were selected and randomly divided into treatment group and control group, 48 cases in each group. The control group was treated with conventional nursing methods, and the experimental group was treated with copper span scraping on the basis of conventional nursing methods. Results: The pulse rate, average systolic and diastolic blood pressure, Hamilton Depression Scale (HAMD) score, and Hamilton Anxiety Scale (HAMA) scores of the two groups of patients after intervention were significantly lower than before treatment (P<0.05). And the experimental group was significantly lower than the control group (P<0.05). Conclusion : The therapy of copper span scraping can effectively relieve the anxiety and depression symptoms of patients with mental disorders, and it is worthy of clinical promotion.